One area of research in this laboratory is computational neuroscience study of the auditory system. In recent years, we have developed neurobiologically-based models for various cell types of the cochlear nucleus (e.g., J. Acoust Soc. Am. 96, 1501-1514, 1994). In these models, cell-specific behavior is reproduced by a particular combination of voltage-dependent ion channels. This research will further develop improved models of the feedback system consisting of cochlear mechanics, inner and outer hair cells, auditory nerve, cochlear nucleus and medial olivocochlear neurons projecting back to the outer hair cells.

From Kim et al. (1994, J. Acoust. Soc. Am. 96, p 1508).
Copyright (C) 1994 Acoustical  Society of  America
If you want to get a whole-page view of the above figure, click inside the figure.

    In spring of each year, Computational Neuroscience Course (MEDS 378) is offered to Neuroscience and Biomedical Engineereing students.  The course description can be found by clicking here .
 

Publications

         Kim, D.O.(1984). “Functional roles of the inner- and outrer-hair-cell subsystems in the cochlea and brainstem” In Hearing Science, C.I. Berlin, Ed., College-Hill Press, San Diego, CA, pp 241-261. Click to view the article .
        Arle, J.E. and Kim, D.O. (1991).  Neural modeling of intrinsic and spike-discharge properties of cochlear nucleus neurons.  Bio. Cybern. 64, 273-283.
       Arle, J.E. and Kim, D.O. (1991). Simulations of cochlear nucleus neural circuitry: Excitatory-inhibitory response-area types I-IV.  J. acoust. Soc. Am. 90, 3106-3120.
        Ghoshal, S., Kim, S. and Northrop, R.B. (1992). Amplitude-modulated tone encoding behavior of cochlear nucleus neurons: Modeling study.  Hearing Res. 58, 153-165.
        Kim, D.O., Ghoshal, S., Khant, S.L., and Parham, K. (1994). A computational model with ionic conductances for the fusiform cell of the dorsal cochlear nucleus. J. Acoust. Soc. Am. 96, 1501-1514.
        Kim, D.O., Ghoshal, S. and Ye, Y. (1998). Integration of ascending and descending signals representing stimulus intensity in the marginal shell of the anteroventral cochlear nucleus. In Psychophysical and Physiological Advances in Hearing, A. R. Palmer et al., Eds., Whurr Pub., London, pp 195-203.
        Kanold, P.O., Kim, D.O. and Manis, P.B. (1999). A computational model of dorsal cochlear nucleus pyramidal cells based on physiological experiments.  Assoc. Res. Otolaryn. Meeting Abst. vol. 22, p 144.
        D'Angelo, W.R., Oliver, D.L. and Kim, D.O. (1999). Modeling cochlear nucleus neurons: Responses to current pulse trains and current steps.  25-th Ann. Northeast Bioeng. Conf., W. Hartford, CT, April, 1999, p 27-28.
        Kim DO, D'Angelo WR. (2000). Computational model for the bushy cell of the cochlear nucleus.  Neurocomputing, 32/33: 189-196.
        Pathmanathan, JS, Kim, DO (2001). A computational model for the AVCN marginal shell with medial olivocochlear feedback: Generation of a wide dynamic range.  Neurocomputing 38-40: 807-815.